Research activities

Research activities

Dr Knowles’ clinical and research interests relate to the biological and psychological interactions of gastrointestinal conditions and the Brain-Gut-Axis. His work (over 50 articles/book chapters, an edited book and another in production) has been published in numerous international journals (e.g., Journal of Crohn's and Colitis, Inflammatory Bowel Disease, The Scandinavian Journal of Gastroenterology, Biological Psychology, Clinical Biochemistry). Due to his extensive experience, Dr Knowles has been an invited chair and speaker at numerous international gastrointestinal-based conferences including Gastro 2015 (Joint conference of the World Gastroenterology Organisation Gastroenterological Society of Australia) and the 15th Asian Pacific Federation of Coloproctology Congress 2015.

Dr Knowles is associated with research projects that have received over 1.8 million in funding from both international and national competitive funding. Dr Knowles is also involved in multiple national and international research projects relating to psychological processes associated with chronic gastrointestinal conditions. Dr Knowles is member of the Program Scientific Committee (allocated $1.2 million to evaluate a psychosocial intervention across multiple physical health conditions including diabetes, stroke, and chronic kidney disease) in a collaborative research project involving St Vincent’s Hospital (Melbourne) and Australian Catholic University. Dr Knowles is a chief investigator for an Australian Research Council (ARC) Discovery Grant (awarded $270,445), with colleagues from St Vincent’s Hospital (Melbourne); project title: Mindfulness and coping in chronic illness: insights from a study of joint replacement surgery.

Dr Knowles has significant expertise in developing and evaluating eHealth research and interventions. He is also the chief investigator and developer of three internationally renowned free online psychological assessment and treatment services for psychological distress associated with Inflammatory Bowel Disease (IBD; www.IBDclinic.org.au) and Irritable Bowel Syndrome (IBS; www.IBSclinic.org.au) and Gastroparesis (www.gastroparesisclinic.org). These websites provide up-to-date medical information about the medical condition, while also providing a free evidenced-based tailored psychological treatment/support services. Dr Knowles is currently developing a website to help individuals who experience toilet anxiety - www.toiletanxiety.org

Edited Books

Knowles, S. R., & Mikocka-Walus, A. A. (September 24th 2014). Psychological Aspects of Inflammatory Bowel Disease A biopsychosocial approach. Routledge Press. (Amazon)

Refereed Book Chapters (Gastrointestinal related only):

Knowles, S. R. (2014). IBD, cancer, and its psychosocial impact (Chapter 11). In Knowles, S. R., & Mikocka-Walus, A. A. edited book Psychological Aspects of Inflammatory Bowel Disease: A biopsychosocial approach. Routledge Press. (Amazon)

Knowles, S. R. (2014). Psychological assessment and the use of questionnaires in IBD cohorts (Chapter 17). In Knowles, S. R., & Mikocka-Walus, A. A. edited book Psychological Aspects of Inflammatory Bowel Disease: A biopsychosocial approach. Routledge Press. (Amazon)

Knowles, S. R. (2014). Future directions in IBD eHealth (Chapter 23). In Knowles, S. R., & Mikocka-Walus, A. A. edited book Psychological Aspects of Inflammatory Bowel Disease: A biopsychosocial approach. Routledge Press. (Amazon)

Nelson, E.A., Knowles, S.R., Jadhava, S.R., Walsh A., & Palombo, A. E. (2013). Assessing the beneficial effects of a magnolia extract supplemented with phosphatidylserine: a randomised, double-blind, placebo-controlled clinical trial. Medicinal Plants: Phytochemistry, Pharmacology and Therapeutics, 13: M/S. Daya Publication House, New Delhi.

Nelson, E. A., Palombo, E. A., & Knowles, S. R. (2010). Comparison of methods for the extraction of bacterial DNA from human faecal samples for analysis by real-time PCR. Current Research, Technology and Education Topics in Applied Microbiology and Microbial Biotechnology.

Refereed Journals (Gastrointestinal related only):

Knowles, S.R., & Skues, J. (2016). Development and Validation of the Shy Bladder and Bowel Scale (SBBS). Cognitive Behaviour Therapy, 45(4), 324-338. http://dx.doi.org/10.1080/16506073.2016.1178800 Impact factor: 2.402

Knowles, S.R., Austin, D.W., Sivanesan, S., Tye-Din, J., Leung, C., Wilson, J., Castle, D., Kamm, M.A., Macrae, F., Hebbard, G. (in press, accepted 17/03/16). Relations between symptom severity, illness perceptions, visceral sensitivity, coping strategies and well-being in irritable bowel syndrome guided by the common sense model of illness. Psychology, Health & Medicine. http://dx.doi.org/10.1080/13548506.2016.1168932 Impact factor: 1.255

Knowles, S.R., Andrews, J., & Porter, A. Crohn’s & Colitis Australia, IBD Support Australia and the Australian Inflammatory Bowel Disease Association (in press; accepted 20/02/2016). Predictors of impaired mental health and support seeking in adults with inflammatory bowel disease: An online survey. Gastroenterology Nursing. Impact factor: 0.688

Jackson, B.D., Gray, K., Knowles, S.R., & De Cruz, P. (in press, accepted 18/02/16). eHealth Technologies in Inflammatory Bowel Disease: A Systematic Review. Journal of Crohn’s and Colitis. http://dx.doi.org/10.1093/ecco-jcc/jjw059 Impact factor: 6.234

Mikocka-Walus, A., Knowles, S.R., Keefer, L., Graff, L. (2016). Controversies revisited: A systematic review of the co-morbidity of depression and anxiety with inflammatory bowel diseases. Inflammatory Bowel Diseases, 22 (3), 752 - 762. Impact Factor: 4.464

Neilson, K., Ftanou, M., Monshat, K., Salzberg, M., Bell, S., Kamm, MA., Connell, W., Knowles, S.R., Sevar, K., Mancuso, S.G., and Castle, D. (2016). A controlled study of a group mindfulness intervention for individuals living with inflammatory bowel disease. Inflammatory Bowel Diseases, 22(3): 694 – 701. Impact Factor: 4.464

Tribbick, D., Salzberg, M., Ftanou, M., Connell, W.R., Macrae, F., Kamm, M.A., Bates, G., Cunningham, G., Austin, D., & Knowles, S. R. (in press; accepted 2015). Differences across illness perceptions in Inflammatory Bowel Disease and their relationships to psychological distress and quality of life. Gastroenterology Nursing. Impact factor: 0.688

Tribbick, D., Salzberg, M., Ftanou, M., Connell, W.R., Macrae, F., Kamm, M.A., Bates, G., Cunningham, G., Austin, D., & Knowles, S. R. (2015). Prevalence of Mental Health Disorders in Inflammatory Bowel Disease: An Australian Outpatients Cohort. Clinical and Experimental Gastroenterology, 8:197-204. doi: 10.2147/CEG.S77567. (Full Text, PDF)

Knowles, S. R., Tribbick, D., Connell, W.R., Castle, D., Salzberg, M., Kamm, M.A. (2014). Exploration of illness perceptions, coping strategies and psychological morbidity in stoma patients. Journal of Wound, Ostomy and Continence Nursing. 41(6):573-80. (Full Text, PDF) Impact factor: 1.142

Knowles, S.R. & Mikocka-Walus, A. (2013) Utilization and efficacy of Internet-based eHealth technology in Gastroenterology: A systematic review. The Scandinavian Journal of Gastroenterology. 49(4):1-16. (Full Text, PDF) Impact factor: 2.2

Knowles, S.R., Monshat K., Castle, D. (2013) The methodological issues and efficacy of psychotherapy for adults with inflammatory bowel disease: a review. Inflammatory Bowel Disease. 19(12):2704-15. (Abstract) Impact Factor: 4.855

Knowles, S., Cook, S. I., & Tribbick, D. T. (2013) Relationship between health status, illness perceptions, coping strategies and psychological morbidity: a preliminary study with IBD stoma patients. Journal of Crohn's and Colitis. 7(10):e471-8. (Abstract) Impact factor: 6.234

Knowles, S. R., Gass, C., & Macrea, F. (2013) Illness perceptions in IBD influence psychological status, sexual health and satisfaction, body image and relational functioning: A preliminary exploration using Structural Equation Modeling. Journal of Crohn's and Colitis. Oct;7(9):e344-50. (Abstract) Impact factor: 2.566

Knowles, S.R., Wilson, J., Wilkinson, A., Connell, W., Salzberg, M., Castle, D., Desmond, P., & Kamm, M.A. (2013). Psychological well-being and quality of life in Crohn's disease patients with an ostomy: a preliminary investigation. Journal of Wound, Ostomy and Continence Nursing. 40(6):623-9. (Abstract) Factor: 1.142

Nelson, E. A., Palombo, E. A., & Knowles, S. R. (2013). Comparison of methods for the extraction of bacterial DNA from human faecal samples for analysis by real-time PCR. Current Research, Technology and Education Topics in Applied Microbiology and Microbial Biotechnology. (Full Text, PDF)

Gondalia, S., Palombo, E., Knowles, S., Cox, S., Meyer, D., & Austin, D. (2012). Molecular characterization of gastrointestinal microbiota in children with autism (with and without gastrointestinal dysfunction) and their neurotypical siblings. Autism Research, Vol. 5, no. 6 (Dec 2012), pp. 419-427. (Full Text, PDF) Impact Factor: 3.686

Knowles, S. R., Wilson, J.L., Connell, W.R., Kamm. M. A. (2011). A preliminary examination of the relations between disease activity, illness perceptions, coping strategies and psychological morbidity in Crohn's disease guided by the common sense model of illness. Inflammatory Bowel Disease, 17(12), 2551-2557. (Full Text, PDF) Impact Factor: 4.855

Gondalia, S., Palombo, E., Knowles, S., Austin, D. (2010). Gastrointestinal microbiology in Autistic Disorder: A review. Reviews in Medical Microbiology, 21, 44-50. (Full Text, PDF) Impact Factor: 0.370

Gondalia, S., Palombo, E., Knowles, S., Austin, D. (2010). Faecal microbiota of individuals with autism spectrum disorder. E-Journal of Applied Psychology (Full Text, PDF)

Refereed Journals (Other publications):

Knowles SR, Nelson EA, Castle DJ, Salzberg MR, Choong PFM, Dowsey. (in press; accepted 20/12/15). Using the common sense model of illness to examine interrelationships between symptom severity and health outcomes in end-stage osteoarthritis patients. Rheumatology. doi: 10.1093/rheumatology/kew022

Knowles, S.R., Castle, D., Biscan, S., Salzberg, S., O'Flaherty, E., & Langham, R. (in press; accepted, 2015). Exploring the relations between health status, illness perceptions, coping strategies and psychological morbidity in kidney transplants patients guided by the common sense model of illness. American Journal of the Medical Sciences.

Austin, D., Spolding, B., Gondalia, S., Shandley, K., Palombo, E., Knowles, S., & Walder, K. (2014). Genetic variation associated with hypersensitivity to mercury. International Toxicology. 21(3): 236–241. (Full Text, HTML) Impact factor: 1.233

Nelson, E.A., Knowles, S.R., Jadhava, S.R., Walsh A., & Palombo, A. E. (2014). Assessing the beneficial effects of a magnolia extract supplemented with phosphatidylserine: a randomised, double-blind, placebo-controlled clinical trial. Medicinal Plants: Phytochemistry, Pharmacology and Therapeutics, (3), p143-152. (Abstract)

Dowsey, M. M., Castle, D. J., Knowles, S. R., Monshat, K., Salzberg, M. R., Choong, P. F. M. (2014). The effect of mindfulness training prior to total joint arthroplasty on post-operative pain and physical function: study protocol for a randomised controlled trial. Trials, 15:208. (Full Text, PDF)

Knowles, S., Swan, L., Salzberg, S., Castle, D., & Langham, R. (2014). Exploring the Relationships Between Health Status, Illness Perceptions, Coping Strategies And Psychological Morbidity in A Chronic Kidney Disease Cohort. American Journal of The Medical Sciences. 348(4):271-6. (Full Text, PDF)

Nelson, A.E., Dowsey, M. M., Knowles, S.R., Castle, D. Salzberg, M, Monshat, K., Dunin, T., & Choong, P.F.M. Systematic Review of the Efficacy of Pre-surgical Mind-Body Based Therapies on Post-operative Outcome Measures. Complementary Therapies in Medicine. 21(6):697-711 (Abstract)

Hyde, M., & Knowles, S. R. (2013) What predicts university students' intentions to volunteer their time for community service? Australian Journal of Psychology. 65(3):135-145. (Full Text, PDF)

Knowles, S. R., Hyde, M. K., & White, K. M. (2012). Predictors of young people's charitable intentions to donate money: An extended theory of planned behaviour perspective. Journal of Applied Social Psychology, 42(9), 2096-2110. doi: 10.1111/j.1559-1816.2012.00932.x (Full Text, PDF)

Knowles, S.R., Nelson, E.A., & Palombo, E.A. (2008). Investigating the role of perceived stress on bacterial flora activity and salivary cortisol secretion: a possible mechanism underlying susceptibility to illness. Biological Psychology, 77, 132-137. (Abstract)

Goldsworthy, B., & Knowles, S. (2008). Caregiving for Parkinson's Disease Patients: An Exploration of a Stress-Appraisal Model for Quality of Life and Burden. Journal of Gerontology: Psychological sciences, 63, 372-376. (Full Text, PDF)

Tucker, P., & Knowles, S. (2008). Review of studies that have used the Standard Shiftwork Index: Evidence for the underlying model of shiftwork and health. Applied Ergonomics, 39, 550-564. (Abstract)

Campbell, A., & Knowles, S. (2007). A Confirmatory Factor Analysis of the GHQ12 using a large scale Australian sample. European Journal of Psychological Assessment, 23(1), 2-8. (Abstract)

Moore, S. & Knowles, S. (2006). Beliefs and Knowledge about Parkinson's Disease. E-Journal of Applied Psychology (Full Text, PDF)

Kambouropoulos, N. & Knowles, S. R. (2006). Psychological distress and responses to blocked and random presentation of emotional Stroop stimuli; an online experiment. E-Journal of Applied Psychology (Full Text, PDF)

Knowles, S., & Bull, D. (2006). Assessing the Relationship Between Age and Personality Variables Measured by the Standard Shiftwork Index on the Psychological and Physiological Well-being of Police Officers. Canadian Journal of Police & Security Services, 4(1), 28-34. (Abstract)

Knowles, S., & Bull, D. (2004). Exploring the mediating roles of cognitive and behavioural coping strategies on the relationship age and well-being. Canadian Journal of Police & Security Services, 2(4), 229-236. (Full Text, PDF)

Knowles, S., & Bull, D. (2004). Investigating the affect of stress on police officer psychological and physiological well-being. Canadian Journal of Police & Security Services, 2(2), 83-89. (Abstract)

Knowles, S., & Bull, D. (2003). Assessing the Impact of Shift Work and Stress on the Psychological and Physiological Wellbeing of Police Officers. Canadian Journal of Police & Security Services, 1(4), 337-342. (Abstract)